Please replace older versions of SDM software by
SDM-PSI
version 6.23, which includes the following new features:
(nearly) unbiased estimation of effect sizes based on
MetaNSUE algorithms.
Familywise correction for multiple comparisons using common
permutation tests, i.e., permuting subject images (PSI). Note
that previous methods used instead tests for spatial convergence,
which relay on spatial assumptions that may not be met and are
have a lower power in the presnce of multiple effects
.
Freedman-Lane-based permutation, for its optimal statistical properties
.
Threshold-free cluster enhancement (TFCE) statistics,
which was neither too conservative nor too liberal in the
simulation work (whereas voxel-based statistics were too
strict and cluster-based statistics too liberal)
.
Seed-based d Mapping (formerly "Signed Differential Mapping") is a statistical technique for
meta-analyzing studies on differences in brain activity or structure
which used neuroimaging techniques such as fMRI, VBM, DTI or PET.
The methods have been fully validated in several studies (see references below),
and meta-analyses using this method have been
already published at the highest quality journals, such as
Archives of General Psychiatry / JAMA Psychiatry
,
the American Journal of Psychiatry
,
Biological Psychiatry
,
Molecular Psychiatry
, or
Neuroscience & Biobehavioral Reviews
,
to cite a few.
Possibility of combining studies from which only
peak coordinates are available with studies from which
SPM t-maps are available, highly increasing the power of
the meta-analysis.
Use of specific masks and correlation templates for fMRI,
PET, gray matter volume, cortical thickness,
white matter,
fractional anisotropy, TBSS and cerebrospinal
fluid to account for the anisotropy in the spatial covariance of the brain,
highly increasing the accuracy of the recreation of the effect size maps.
Accounting for peaks' effect-size and sign
to counteract positive and negative differences.
Weighting the calculations for intra-study variance (i.e.
studies with large sample sizes and/or lower error contribute
more) and inter-study heterogeneity.
Complementary analyses such as exploration of heterogeneity
(by means of heterogeneity maps, subgroup analyses
and meta-regressions)
and jackknife analyses (to assess
the replicability of the results).
The software
Please feel free
to download the software created by the
SDM Project to carry out such meta-analyses.
References
Introduction to voxel-based meta-analyses:
Radua J and Mataix-Cols D. Meta-analytic methods for
neuroimaging data explained.
Biol Mood Anxiety Disord 2012; 2:6.
Müller VI et al. Ten simple rules for neuroimaging meta-analysis.
Neurosci Biobehav Rev 2018; 84:151-161.
SDM methods:
First method (SDM):
Radua J and Mataix-Cols D. Voxel-wise
meta-analysis of grey matter changes in obsessive-compulsive disorder.
Br J Psychiatry 2009; 195:393-402.
Meta-comparisons:
Radua J, van den Heuvel OA, Surguladze S and
Mataix-Cols D. Meta-analytical comparison of voxel-based morphometry studies
in obsessive compulsive disorder vs other anxiety disorders.
Arch Gen Psychiatry 2010; 67:701-711.
Effect sizes (ES-SDM):
Radua J, Mataix-Cols D, Phillips ML, El-Hage W, Kronhaus DM, Cardoner N and
Surguladze S. A new meta-analytic method for neuroimaging studies that combines
reported peak coordinates and statistical parametric maps.
Eur Psychiatry 2012; 27:605–611.
Anisotropic kernels (AES-SDM):
Radua J, Rubia K, Canales-Rodriguez EJ, Pomarol-Clotet E, Fusar-Poli P
and Mataix-Cols D. Anisotropic kernels for coordinate-based meta-analyses
of neuroimaging studies.
Front Psychiatry 2014; 5:13.
[issues of previous methods]Test for spatial convergence:
Albajes-Eizagirre A and Radua J. What do results from
coordinate-based meta-analyses tell us?
Neuroimage 2018; 176:550-553.
[main paper of the current method]Permutation of subject images (SDM-PSI):
Albajes-Eizagirre A, Solanes A, Vieta E and Radua J.
Voxel-based meta-analysis via permutation of subject images (PSI):
Theory and implementation for SDM.
Neuroimage 2019; 186:174-184.
SDM specific white matter, TBSS and FreeSurfer templates:
White matter:
Radua J, Via E, Catani M and
Mataix-Cols D. Voxel-based meta-analysis of regional white-matter volume
differences in autism spectrum disorder versus healthy controls.
Psychol Med 2011; 41:1539-1550.
Fractional anistropy (TBSS):
Peters BD, Szeszko PR, Radua J, Ikuta T, Gruner P, DeRosse P,
Zhang JP, Giorgio A, Qiu D, Tapert SF, Brauer J, Asato MR, Khong PL,
James AC, Gallego JA and
Malhotra AK. White matter development in adolescence: diffusion tensor imaging and meta-analytic results.
Schizophrenia Bull 2012; 38:1308-1317.
Cortical thickness (FreeSurfer):
Li Q, Zhao Y, Chen Z, Long J, Dai J, Huang X, Lui S, Radua J,
Vieta E, Kemp GJ, Sweeney JA, Li F and Gong Q. Meta-analysis
of cortical thickness abnormalities in medication-free patients
with major depressive disorder.
Neuropsychopharmacology 2019; in Press.
Improved atlas:
Radua J, Grau M, van den Heuvel OA, de Schotten MT, Stein DJ,
Canales-Rodriguez EJ, Catani M and Mataix-Cols D.
Multimodal voxel-based meta-analysis of white matter abnormalities
in obsessive-compulsive disorder.
Neuropsychopharmacology 2014; 39:1547-57.
Thiebaut de Schotten M, Dell'Acqua F, Forkel SJ, Simmons A, Vergani F,
Murphy DG and Catani M.
A lateralized brain network for visuospatial attention.
Nat Neurosci 2011; 14:1245-1246.
Thiebaut de Schotten M, Ffytche DH, Bizzi A, Dell'Acqua F, Allin M,
Walshe M, Murray R, Williams SC, Murphy DG and Catani M.
Atlasing location, asymmetry and inter-subject variability of white
matter tracts in the human brain with MR diffusion tractography.
Neuroimage 2011; 54:49-59.
Other known studies using SDM (probably not all of them): [THIS LIST WAS LAST UPDATED IN 2014]
Bora E, Fornito A, Yücel M and
Pantelis C. Voxelwise meta-analysis of gray matter abnormalities
in bipolar disorder.
Biol Psychiatry 2010; 67:1097-1105.
Chen Z and Ma L. Grey matter volume changes over the
whole brain in amyotrophic lateral sclerosis: A voxel-wise
meta-analysis of voxel based morphometry studies.
Amyotroph Lateral Scler 2010; 11:549-554.
Bora E, Fornito A, Radua J, Walterfang M, Seal M, Wood SJ, Yücel M,
Velakoulis D and Pantelis C. Neuroanatomical abnormalities
in schizophrenia: A multimodal voxelwise meta-analysis and
meta-regression analysis.
Schizophr Res 2011; 127:46-57.
Richlan F, Kronbichler M and Wimmer H. Meta-analyzing brain
dysfunctions in dyslexic children and adults.
Neuroimage 2011; 56:1735-42.
E Via, J Radua, N Cardoner, F Happe and D Mataix-Cols. Meta-analysis
of gray matter abnormalities in autism spectrum disorder: should Asperger
disorder be subsumed under a broader umbrella of autistic spectrum disorder?
Arch Gen Psychiatry 2011; 68:409-418.
Lai CH. Gray matter deficits in panic disorder: a pilot study of
meta-analysis.
J Clin Psychopharmacol 2011; 31:287-93.
Bora E, Fornito A, Pantelis C and Yücel M. Gray matter abnormalities
in Major Depressive Disorder: A meta-analysis of voxel based morphometry
studies.
J Affect Disord 2012; 138:9-18.
Li J, Pan P, Song W, Huang R, Chen K and Shang H. A meta-analysis
of diffusion tensor imaging studies in amyotrophic lateral sclerosis.
Neurobiol Aging 2012; 33:1833–1838.
Pan PL, Song W and Shang HF. Voxel-wise meta-analysis of gray
matter abnormalities in idiopathic Parkinson's disease.
Eur J Neurol 2011; 19:199-206.
Bora E, Fornito A, Yücel M and Pantelis C. The effects of
gender on grey matter abnormalities in major psychoses: a comparative
voxelwise meta-analysis of schizophrenia and bipolar disorder.
Psychol Med 2011; 42:295-307.
Nakao T, Radua J, Rubia K and Mataix-Cols D. Gray matter volume
abnormalities in ADHD: Voxel-based meta-analysis exploring the effects of
age and stimulant medication.
Am J Psychiatry 2011; 168:1154-1163.
Murphy ML and Frodl T. Meta-analysis of diffusion tensor
imaging studies shows altered fractional anisotropy occurring in
distinct brain areas in association with depression.
Biol Mood Anxiety Disord 2011; 1:3.
Fusar-Poli P, Radua J, McGuire P and Stefan B. Neuroanatomical
maps of psychosis onset: Voxel-wise meta-analysis of antipsychotic-naive
VBM studies.
Schizophrenia Bull 2012; 38:1297-1307.
Frodl T and Skokauskas N. Meta-analysis of structural MRI
studies in children and adults with attention deficit hyperactivity
disorder indicates treatment effects.
Acta Psychiatr Scand 2012; 125:114-26.
Fusar-Poli P. Voxel-wise meta-analysis of fMRI studies in patients at
clinical high risk for psychosis.
J Psychiatry Neurosci 2012;37:106-12.
Li J, Pan P, Huang R and Shang H. A meta-analysis of voxel-based
morphometry studies of white matter volume alterations in Alzheimer's
disease.
Neurosci Biobehav R 2012;36:757-63.
Fusar-Poli P, Smieskova R, Serafini G, Politi P and Borgwardt S.
Neuroanatomical markers of genetic liability to psychosis and first
episode psychosis: A voxelwise meta-analytical comparison.
World J Biol Psychia 2014;15:219-28.
Palaniyappan L, Balain V, Radua J and Liddle PF. Structural
correlates of auditory hallucinations in schizophrenia: A meta-analysis.
Schizophr Res 2012; 137:169–173.
Richlan F, Kronbichler M and Wimmer H. Structural abnormalities
in the dyslexic brain: A meta-analysis of voxel-based morphometry studies.
Hum Brain Mapp 2012; 34:3055-65.
Pan PL, Song W, Yang J, Huang R, Chen K, Gong QY, Zhong JG, Shi HC
and Shang HF. Gray matter atrophy in behavioral variant
frontotemporal dementia: a meta-analysis of voxel-based morphometry studies.
Dement Geriatr Cogn Disord 2012; 33:141-8.
Palaniyappan L, Balain V and Liddle PF. The neuroanatomy of
psychotic diathesis: A meta-analytic review.
J Psychiatr Res 2012; 46:1249–1256.
Bohrn IC, Altmann U and Jacobs AM. Looking at the brains behind
figurative language - A quantitative meta-analysis of neuroimaging
studies on metaphor, idiom, and irony processing.
Neuropsychologia 2012; 50:2669–2683.
Radua J, Borgwardt S, Crescini A, Mataix-Cols D, Meyer-Lindenberg A,
McGuire PK and Fusar-Poli P. Multimodal meta-analysis of
structural and functional brain changes in first episode psychosis
and the effects of antipsychotic medication.
Neurosci Biobehav Rev 2012; 36:2325–2333.
Hart H, Radua J, Mataix-Cols D and Rubia K. Meta-analysis
of fMRI studies of timing in attention-deficit hyperactivity disorder
(ADHD).
Neurosci Biobehav Rev 2012; 36:2248-56.
Lai CH. Gray matter volume in major depressive disorder: a
meta-analysis of voxel-based morphometry studies.
Psychiatry Res 2013; 211:37-46.
Peng Z, Lui SS, Cheung EF, Jin Z, Miao G, Jing J and Chan RC.
Brain structural abnormalities in obsessive-compulsive disorder:
converging evidence from white matter and grey matter.
Asian J Psychiatr 2012; 5:290-296.
Pan PL, Shi HC, Zhong JG, Xiao PR, Shen Y, Wu LJ, Song YY, He GX
and Li HL. Gray matter atrophy in Parkinson's disease with
dementia: evidence from meta-analysis of voxel-based morphometry studies.
Neurol Sci 2013; 34:613-619.
Pan P, Shi H, Zhong J, Xiao P, Shen Y, Wu L, Song Y and He G.
Chronic smoking and brain gray matter changes: evidence from meta-analysis
of voxel-based morphometry studies.
Neurol Sci 2012; 34:813-7.
Hart H, Radua J, Nakao T, Mataix-Cols D and Rubia K.
Meta-analysis of functional magnetic resonance imaging studies of
inhibition and attention in attention-deficit/hyperactivity disorder:
exploring task-specific, stimulant medication, and age effects.
JAMA Psychiatry 2013; 70:185-98.
Lansley J, Mataix-Cols D, Grau M, Radua J and Sastre-Garriga J.
Localized grey matter atrophy in multiple sclerosis: A meta-analysis
of voxel-based morphometry studies and associations with functional
disability.
Neurosci Biobehav Rev 2013; 37:819-830.
Ersche KD, Williams GB, Robbins TW and Bullmore ET. Meta-analysis
of structural brain abnormalities associated with stimulant drug
dependence and neuroimaging of addiction vulnerability and resilience.
Curr Opin Neurobiol 2013; 23:615-24.
Jacobs HI, Radua J, Lückmann HC and Sack AT. Meta-analysis
of functional network alterations in Alzheimer's disease: Toward
a network biomarker.
Neurosci Biobehav Rev 2013; 37:753-765.
Sartory G, Cwik J, Knuppertz H, Schürholt B, Lebens M, Seitz RJ
and Schulze R. In search of the trauma memory: a meta-analysis
of functional neuroimaging studies of symptom provocation in
posttraumatic stress disorder (PTSD).
PLoS One 2013; 8:e58150.
Shi HC, Zhong JG, Pan PL, Xiao PR, Shen Y, Wu LJ, Li HL, Song YY,
He GX and Li HY. Gray matter atrophy in progressive supranuclear
palsy: meta-analysis of voxel-based morphometry studies.
Neurol Sci 2013; 34:1049-55.
McCarthy H, Skokauskas N and Frodl T. Identifying a consistent
pattern of neural function in attention deficit hyperactivity disorder:
a meta-analysis.
Psychol Med 2013; 44:869-80.
Alves J, Soares JM, Sampaio A and Gonçalves OF. Posterior
cortical atrophy and Alzheimer's disease: a meta-analytic review
of neuropsychological and brain morphometry studies.
Brain Imaging Behav 2013;7:353-61.
Nortje G, Stein DJ, Radua J, Mataix-Cols D and Horn N.
Systematic review and voxel-based meta-analysis of diffusion
tensor imaging studies in bipolar disorder.
J Affect Disord 2013;150:192-200.
Aoki Y, Inokuchi R, Nakao T and Yamasue H. Neural bases of
antisocial behavior: a voxel-based meta-analysis.
Soc Cogn Affect Neurosci 2014;9:1223-31.
Cao B, Tang Y, Li J, Zhang X, Shang HF and Zhou D. A meta-analysis
of voxel-based morphometry studies on gray matter volume alteration in
juvenile myoclonic epilepsy.
Epilepsy Res 2013; 106:370-7.
Hajek T, Alda M, Hajek E and Ivanoff J. Functional neuroanatomy
of response inhibition in bipolar disorders - Combined voxel based and
cognitive performance meta-analysis.
J Psychiatr Res 2013; 47:1955-66.
Schurz M, Aichhorn M, Martin A and Perner J. Common brain
areas engaged in false belief reasoning and visual perspective
taking: a meta-analysis of functional brain imaging studies.
Front Hum Neurosci 2013;7:712.
Lin CS, Niddam DM and Hsu ML. Meta-analysis on brain
representation of experimental dental pain.
J Dent Res 2014; 93:126-33.
Cooper D, Barker V, Radua J, Fusar-Poli P and Lawrie SM.
Multimodal voxel-based meta-analysis of structural and functional
magnetic resonance imaging studies in those at elevated genetic
risk of developing schizophrenia.
Psychiatry Res 2014; 221:69-77.
Rubia K, Alegria AA, Cubillo AI, Smith AB, Brammer MJ and
Radua J. Effects of stimulants on brain function in
attention-deficit/hyperactivity disorder: a systematic review and
meta-analysis.
Biol Psychiatry 2014;76:616-28.
Xiao Y, Zhang W, Lui S, Yao L and Gong Q. Similar and different
gray matter deficits in schizophrenia patients and their
unaffected biological relatives.
Front Psychiatry 2013; 4:150.
White TP, Engen NH, Sorensen S, Overgaard M and Shergill SS.
Uncertainty and confidence from the triple-network perspective:
voxel-based meta-analyses..
Brain Cogn 2014; 85C:191-200.
Schurz M, Radua J, Aichhorn M, Richlan F and Perner J.
Fractionating Theory of Mind: a meta-analysis of functional brain
imaging studies.
Neurosci Biobehav Rev 2014;42:9-34.
Shang J, Fu Y, Ren Z, Zhang T, Du M, Gong Q, Lui S and
Zhang W. The common traits of the ACC and PFC in anxiety disorders
in the DSM-5: meta-analysis of voxel-based morphometry studies.
PLoS One 2014;9:e93432.
Goozee R, Handley R, Kempton MJ and Dazzan P. A systematic
review and meta-analysis of the effects of antipsychotic
medications on regional cerebral blood flow (rCBF) in schizophrenia:
association with response to treatment.
Neurosci Biobehav Rev 2014;43:118-36.
Radua J, Del Pozo NO, Gómez J, Guillen-Grima F and Ortuño F.
Meta-analysis of functional neuroimaging studies indicates that an
increase of cognitive difficulty during executive tasks engages
brain regions associated with time perception.
Neuropsychologia 2014;58:14-22.
Rocchetti M, Radua J, Paloyelis Y, Xenaki LA, Frascarelli M,
Caverzasi E, Politi P and Fusar-Poli P. Neurofunctional
maps of the 'maternal brain' and the effects of oxytocin: a
multimodal voxel-based meta-analysis.
Psychiatry Clin Neurosci 2014;68:733-51.
Lim L, Radua J and Rubia K. Gray matter abnormalities in
childhood maltreatment: a voxel-wise meta-analysis.
Am J Psychiatry 2014;171:854-63.
Liu Y, Yu JT, Wang HF, Han PR, Tan CC, Wang C, Meng XF, Risacher
SL, Saykin AJ and Tan L. APOE genotype and neuroimaging
markers of Alzheimer's disease: systematic review and meta-analysis.
J Neurol Neurosurg Psychiatry 2014; in Press.
Meng Y, Qiu C, Zhu H, Lama S, Lui S, Gong Q and Zhang W.
Anatomical deficits in adult posttraumatic stress disorder: a
meta-analysis of voxel-based morphometry studies.
Behav Brain Res 2014;270:307-15.
Meng Y1, Deng W, Wang H, Guo W and Li T. The prefrontal
dysfunction in individuals with Internet gaming disorder: a
meta-analysis of functional magnetic resonance imaging studies.
Addict Biol 2014; in Press.
Lisofsky N, Kazzer P, Heekeren HR and Prehn K. Investigating
socio-cognitive processes in deception: a quantitative
meta-analysis of neuroimaging studies.
Neuropsychologia 2014; 2014;61:113-22.
Du M, Liu J, Chen Z, Huang X, Li J, Kuang W, Yang Y, Zhang W,
Zhou D, Bi F, Kendrick KM and Gong Q. Brain grey matter
volume alterations in late-life depression.
J Psychiatry Neurosci 2014;39:397-406.
Scognamiglio C and Houenou J. A meta-analysis of fMRI
studies in healthy relatives of patients with schizophrenia.
Aust N Z J Psychiatry 2014;48:907-16.
Zhong J, Pan P, Dai Z and Shi H. Voxelwise meta-analysis
of gray matter abnormalities in dementia with Lewy bodies.
Eur J Radiol 2014;83:1870-4.
Zhao YJ, Du MY, Huang XQ, Lui S, Chen ZQ, Liu J, Luo Y, Wang XL,
Kemp GJ and Gong QY. Brain grey matter abnormalities in
medication-free patients with major depressive disorder: a meta-analysis.
Psychol Med 2014;44:2927-37.
Wang XL, Du MY, Chen TL, Chen ZQ, Huang XQ, Luo Y, Zhao YJ,
Kumar P and Gong QY. Neural correlates during working
memory processing in major depressive disorder.
Prog Neuropsychopharmacol Biol Psychiatry 2015:56:101–108.
Meng YJ, Deng W, Wang HY, Guo WJ, Li T, Lam C and Lin X.
Reward pathway dysfunction in gambling disorder: A meta-analysis
of functional magnetic resonance imaging studies.
Behav Brain Res 2014;275C:243-251.
Aoki Y, Cortese S and Tansella M. Neural bases of atypical
emotional face processing in autism: A meta-analysis of fMRI studies.
World J Biol Psychiatry 2014; in Press.
He W, Liu D, Radua J, Li G, Han B and Sun Z. Meta-analytic
comparison between PIB-PET and FDG-PET results in Alzheimer's
Disease and MCI.
Cell Biochem Biophys 2015;71:17-26.
Welton T, Kent D, Constantinescu CS, Auer DP and Dineen RA.
Functionally relevant white matter degradation in multiple sclerosis:
A tract-based spatial meta-analysis.
Radiology 2014; in Press.
Gabay AS, Radua J, Kempton MJ and Mehta MA. The Ultimatum
Game and the brain: A meta-analysis of neuroimaging studies.
Neurosci Biobehav Rev 2014;47C:549-558.
Martin A, Schurz M, Kronbichler M and Richlan F. Reading
in the brain of children and adults: a meta-analysis of 40
functional magnetic resonance imaging studies.
Hum Brain Mapp 2015;36:1963-81.
Do you know other published studies using SDM? Please tell us at joaquim dot radua at kcl dot ac dot uk !
version 6.23, which includes the following new features: